Epa endocrine disruptors program

The initiative, referred to as EDSP21 — or EDSP in the 21 st century — aims to use computational or in silico models and molecular based in vitro high-throughput screening HTS assays to prioritize and screen chemicals to determine their potential to interact with the estrogen, androgen or thyroid E, A, or T bioactivity.

In addition to leveraging advances in technology, the initiative also emphasizes strategic coordination and timing of chemical evaluations in the context of existing regulatory frameworks.

By issuing test orders for an active ingredient before the start of the registration review process for the active ingredient, the results of any EDSP Tier 2 tests that might be needed for the active ingredient should be available for agency scientists to review when they are also examining the toxicology database to develop updated and more expeditious risk assessments. Reviewing both sets of data concurrently will reduce duplication of effort and lead to decisions more expediently.

However, the time needed to fulfill test order requirements using the current validated Tier 1 assays can make it challenging to integrate data from the current EDSP Tier 1 assays into the reregistration review of some pesticides. This would mean that the data for some active ingredients may not be available early enough to be easily integrated into their registration review.

Official websites use. Share sensitive information only on official, secure websites. JavaScript appears to be disabled on this computer. Please click here to see any active alerts. The FIFRA SAP will continue to evaluate relevant scientific issues, protocols, data, and interpretations of the data for the assays during the validation process. Contact Us to ask a question, provide feedback, or report a problem.

Jump to main content. Contact Us. Program History In the 's, some scientists proposed that certain chemicals might be disrupting the endocrine systems of humans and wildlife. Top of Page.